Product ID:PYRIDINE HPLC GRADE, 270407
MSDS Date:07/01/1999
FSC:6810
NIIN:00N092614
Status Code:A
MSDS Number: CJTND

Emergency Phone: 314-771-5765

Info Phone: 314-771-5765

Cage: 21076

Telephone: 314-771-5765

Cage: 21076

(ORAL,RAT) 891 MG/KG.

CAS: 110-86-1

RTECS: UR8400000

OSHA PEL 15 MG/M3;5 PPM

ACGIH TLV: 16 MG/M3;5 PPM

EPA Report Quantity: 1000 LBS

DOT Report Quantity: 1000 LBS

LD50 LC50 Mixture:SEE INGREDIENT & TOXICOLOGICAL INFO.
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:ACUTE: HARMFUL IF SWALLOWED, INHALED
OR ABSORBED THROUGH SKIN. CAUSES SEVERE IRRITATION. HIGH
CONCENTRATIONS ARE EXTREMELY DESTRUCTIVE TO TISSUES OF THE MUCOUS
MEMBRANES AND UPPER RESPIRATORY TRACT, E YES AND SKIN. SYMPTOMS OF
EXPOSURE MAY INCLUDE BURNING SENSATION, COUGHING, WHEEZING,
LARYNGITIS, SHORTNESS OF BREATH, HEADACHE, NAUSEA AND VOMITING.
DOSE-RELATED SIDE EFFECTS MAY INCLUDE: ANOREXIA, N AUSEA, VOMITING,
HEADACHE, DIZZINESS, TACHYCARDIA, NERVOUSNESS, INSOMNIA, SKIN
DISORDERS. READILY ABSORBED THROUGH SKIN. CHRONIC: TARGET ORGAN(S):
LIVER, KIDNEYS, NERVES, BONE MARROW. TARGET ORGAN DAT A: PERIPHERAL
NERVE AND(EFTS OF OVEREXP)
Effects of Overexposure:HLTH HAZS: SENSATION (FLACCID PARALYSIS WITHOUT
ANESTHESIA). SENSE ORGANS AND SPECIAL SENSES (PTOSIS). BEHAVIORAL
(GENERAL ANESTHETIC; SLEEP; SOMNOLENCE; TREMOR; ATAXIA; COMA).
CARDIAC (CHANGE IN RATE ). VASCULAR (BP LOWERING NOT CHARACTERIZED
IN AUTONOMIC SECTION). LUNGS, THORAX OR RESPIRATION (DYSPNAE;
RESPIRATORY DEPRESSION; OTHER CHANGES). GASTROINTESTINAL (CHANGES
IN STRUCTURE OR FUNCTION OF S ALIVARY GLANDS). LIVER (OTHER
CHANGES).

First Aid:EYES: IMMEDIATELY FLUSH WITH COPIOUS AMOUNTS OF WATER FOR AT
LEAST 15 MINUTES. ASSURE ADEQUATE FLUSHING BY SEPARATING EYELIDS
WITH FINGERS. SKIN: IMMEDIATELY FLUSH WITH COPIOUS AMOUNTS OF WATER
FOR AT LEAST 15 MINUTES WHILE REMOVING CONTAMINATED CLOTHING AND
SHOES. WASH CONTAMINATED CLOTHING BEFORE REUSE. INHALATION: REMOVE
TO FRESH AIR. IF NOT BREATHING GIVE ARTIFICIAL RESPIRATION. IF
BREATHING I S DIFFICULT, GIVE OXYGEN. INGESTION: WASH OUT MOUTH
WITH WATER PROVIDED PERSON IS CONSCIOUS. CALL MD.

Flash Point:=20.C, 68.F
Autoignition Temp:=481.7C, 899.F
Lower Limits:1.8%
Upper Limits:12.4%
Extinguishing Media:CARBON DIOXIDE, DRY CHEMICAL POWDER OR APPROPRIATE
FOAM. WATER MAY BE EFFECTIVE FOR COOLING, BUT MAY NOT EFFECT
EXTINGUISHMENT.
Fire Fighting Procedures:USE NIOSH APPROVED SCBA AND FULL PROTECTIVE
EQUIPMENT . FLAMMABLE.
Unusual Fire/Explosion Hazard:VAPOR MAY TRAVEL CONSIDERABLE DISTANCE TO
SOURCE OF IGNITION AND FLASH BACK. FORMS EXPLOSIVE MIXTURES IN AIR.
EMITS TOXIC FUMES UNDER FIRE CONDITIONS.

Spill Release Procedures:EVACUATE AREA. SHUT OFF ALL SOURCES OF
IGNITION. WEAR NIOSH APPROVED SELF-CONTAINED BREATHING APPARATUS,
RUBBER BOOTS AND HEAVY RUBBER GLOVES. COVER WITH DRY-LIME, SAND OR
SODA ASH. PLACE IN COVERED C ONTAINER USING NON-SPARKING TOOLS AND
TRANSPORT OUTDOORS. VENTILATE AREA AND WASH SPILL SITE AFTER
MATERIAL PICKUP IS COMPLETE.
Neutralizing Agent:DRY-LIME, SAND OR SODA ASH.

Handling and Storage Precautions:DO NOT BREATHE VAPOR. DO NOT GET IN
EYES, ON SKIN, ON CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE.
KEEP TIGHTLY CLOSED. KEEP AWAY FROM HEAT, SPARKS AND OPEN FLAME.
STORE IN A COOL, DRY PLACE.
Other Precautions:HIGHLY FLAMMABLE (EU). HARMFUL. KEEP AWAY FROM
SOURCES OF IGNITION - NO SMOKING.

Respiratory Protection:WEAR APPROPRIATE NIOSH APPROVED RESPIRATOR.
Ventilation:USE ONLY IN A CHEMICAL FUME HOOD.
Protective Gloves:CHEMICAL-RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:ANSI APPROVED EYE WASH & DELUGE SHOWER .
WEAR SUITABLE OTHER PROTECTIVE CLOTHING. USE NONSPARKING TOOLS.
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
MFR'S INFORMATION ON INGREDIENTS: EC NO: 203-809-9. -- PHYSICAL &
CHEMICAL PROPERTIES: SOLUBILITY: ETHER - SOLUBLE; BENZENE -
SOLUBLE; ETHANOL - SOLUBLE; LIGROIN - SOLUBLE.

Boiling Pt:=115.C, 239.F
Melt/Freeze Pt:=-42.C, -43.6F
Vapor Pres:20MM @ 25C; 10MM @ 13.2C
Vapor Density:2.72
Spec Gravity:0.978
Solubility in Water:SOLUBLE
Appearance and Odor:COLORLESS LIQUID; UNPLEASANT ODOR.

Stability Indicator/Materials to Avoid:YES
ACIDS, ACID CHLORIDES, OXIDIZING AGENTS, CHLOROFORMATES.
Hazardous Decomposition Products:THERMAL DECOMPOSITION MAY PRODUCE
CARBON MONOXIDE, CARBON DIOXIDE, AND NITROGEN OXIDES.
Conditions to Avoid Polymerization:WILL NOT OCCUR.

Waste Disposal Methods:BURN IN A CHEMICAL INCINERATOR EQUIPPED WITH AN
AFTERBURNER AND SCRUBBER BUT EXERT EXTRA CARE IN IGNITING AS THIS
MATERIAL IS HIGHLY FLAMMABLE. OBSERVE ALL FEDERAL, STATE AND LOCAL
ENVIRONMENTAL REGUL ATIONS. RCRA WASTE NUMBER: U196.

Toxicological Information:TO BEST OF MFR'S KNOWLEDGE, CHEM, PHYSICAL &
TOXICOLOGICAL PROPERTIES HAVE NOT BEEN THORO INVESTIGATED. IRRIT
DATA: SKIN-RBT 500 MG/24 H MLD - 85JCAE -,839,1986. TOX DATA:
LD50:(ORL,RAT) 891 MG/KG; LC 50:(IHL,RAT) 28,500 MG/M3/1H;
LD50:(SKN,RBT) 1121 MG/KG - BIOFX* 14-4/1970. LD50:(IPR,RAT) 866
MG/KG - NTIS** PB195-158. LD50:(SCU,RAT) 866 MG/KG - CTOXAO
4,185,1971. LD50:(IVN,RAT) 360 MG/KG; LD50:(O RL,MUS) 1500 MG/KG;
LD50:(SCU,MUS) 1250 MG/KG; LD50:(IVN,MUS) 420 MG/KG - PLRCAT
5,341,1973. LD50:(IPR,MUS) 950 MG/KG - PBPHAW 1,542,1965.
LD50:(IVN,DOG) 880 MG/KG - TXCYAC 4,165,1975. LD50:(SKN,GPG) 1
GM/KG - (ECOLOGICAL INFO)

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.

Ecological:DATA NOT YET AVAILAB;E. -- TOXICOLOGICAL INFO: 85JCAE
-,839,1986. LD50:(ORL,MAM) 1500 MG/KG; LC50:(IHL,MAM) 10 GM/M3 -
GTPZAB 32(10),25,1988. ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF
CHEMICAL SUBSTA NCES (RTECS) DATA IS PRESENTED HERE. SEE ACTUAL
ENTRY IN RTECS FOR COMPLETE INFORMATION.

Transport Information:CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION
INFORMATION. -- OTHER INFO: DATA BASE, DECEMBER 1998. NIOSH
ANALYTICAL METHOD, 1994: PYRIDINE, 1613. NIOSH ANALYTICAL METHOD,
1996: PYRIDINE, 1613. NT P CARCINOGENEIS STUDIES; TEST COMPLETED
(POST PEER REVIEW), NOVEMBER 1998.

SARA Title III Information:U.S. INFORMATION: THIS PRODUCT IS SUBJECT TO
SARA SECTION 313 REPORTING REQUIREMENTS.
Federal Regulatory Information:EUROPEAN INFO: EC INDEX NO:
613-002-00-7. HIGHLY FLAMM. HARMFUL. R 11 - HIGHLY FLAMM. R
20/21/22 - HARMFUL BY INHAL, IN CONT W/SKIN & IF SWALLOWED. S 26 -
IN CASE OF CONT W/EYES, RINSE IMMED W/PLENTY OF WATER & SEEK MED
ADVICE. S 28 - AFTER CONT W/SKIN, WASH IMMED W/PLENTY OF WATER.
REVIEWS, STDS & REGS: OEL=MAK. ACGIH TLV-TWA 16 MG/M3 (5 PPM) -
DTLVS* TLV/BEI,1997. MSHA STD-AIR:TWA 5 PPM (15 MG /M3) - DTLVS*
3,220,1971. OSHA PEL (GEN INDU):8H TWA 5 PPM (15 MG/M3) - CFRGBR
29,1910.1000,1994. OS HA PEL (CONSTRUC):8H TWA 5 PPM (15 MG/M3) -
CFRGBR 29,1926.55,1994. OSHA PEL (SHIPYARD):8H TWA 5 PPM (15 MG/M3)
- (STATE REGULATORY INFO)
State Regulatory Information:FED REGULATORY: CFRGBR 29,1915.1000,1993.
OSHA PEL (FED CONT):8H TWA 5 PPM (15 MG/M3) - CFRGBR
41,50-204.50,1994. OEL-ARAB REPUBLIC OF EGYPT; AUSTRALIA; DENMARK;
GERMANY; THE NETHERLANDS; TURKEY:TWA 5 PPM (15 MG/M3) JAN 1993.
OEL-BELGIUM:TWA 5 PPM (16 MG/M3) JAN 1993. OEL-FINLAND:TWA 5 PPM
(15 MG/M3); STEL 10 PPM (30 MG/M3); SKIN JAN 1993. OEL-FRANCE;
SWITZERLAND; UNITED KINGDOM:TWA 5 PPM (15 MG/M 3); STEL 10 PPM (30
MG/M3) JAN 1993. OEL-HUNGARY:TWA 5 MG/M3; STEL 10 MG/M3; SKIN JAN
1993. OEL-THE PHILIPPINES; POLAND:TWA 5 MG/M3 JAN 1993.
OEL-RUSSIA:STEL 5 MG/M3 JAN 1993. OEL-SWEDEN:TWA 5 PPM (16 MG/M3);
STEL 10 PPM (OTHER INFO)